Welcome to the Society for Clinical Trials

A Message from 2015-2016 SCT President, Wendy Parulekar, MD

2015-2016 SCT President, Wendy Parulekar, MD

Welcome to the Society for Clinical Trials (SCT) an international and multidisciplinary society of individuals who share a passion and commitment to advancing the methodology and conduct of clinical trials. The function of the Society as a forum to discuss and debate the role of clinical trials in the research enterprise has never been more important as we are faced with the challenges of designing efficient trials to address the most compelling clinical questions in a research environment characterized by limited resources and information overload. Implicit in the mandate of designing efficient trials is the need to demonstrate the value or usefulness of randomized clinical trials to the consumers of this research. It is not enough to state that randomized clinical trials represent the highest level of evidence to guide decision making - we need to demonstrate that this type of research matters. Your membership in the SCT provides an excellent opportunity to voice your opinions on these issues and others. read more »


Enhancing clinical evidence by proactively building quality into clinical trials

A post hoc evaluation of a sample size re-estimation in the Secondary Prevention of Small Subcortical Strokes study

Generalized estimating equations in cluster randomized trials with a small number of clusters: Review of practice and simulation study

Subpopulation Treatment Effect Pattern Plot (STEPP) analysis for continuous, binary, and count outcomes

Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students

The Diabetes Telephone Study: Design and challenges of a pragmatic cluster randomized trial to improve diabetic peripheral neuropathy treatment

Response from the authors

Commentary on Schulz et al.

Patient-oriented randomisation: A new trial design applied in the Neuroleptic Strategy Study

The design and implementation of a randomized controlled trial of a risk reduction and human immunodeficiency virus prevention videogame intervention in minority adolescents: PlayForward: Elm City Stories

Did death certificates and a death review process agree on lung cancer cause of death in the National Lung Screening Trial?

Addressing challenges of clinical trials in acute pain: The Pain Management of Vaso-occlusive Crisis in Children and Young Adults with Sickle Cell Disease Study

Use of an embedded, micro-randomised trial to investigate non-compliance in telehealth interventions

Alexander of Tralles and the first portrayal of a placebo by illusion in the 6th century AD

Adherence adjustment in the Coronary Drug Project: A call for better per-protocol effect estimates in randomized trials

Commentary on Murray and Hernan

Substantial risks associated with few clusters in cluster randomized and stepped wedge designs

Cluster-randomized trials: A closer look

Commentary on McRae et al.

Selection of the effect size for sample size determination for a continuous response in a superiority clinical trial using a hybrid classical and Bayesian procedure

Recruitment strategies and challenges in a large intervention trial: Systolic Blood Pressure Intervention Trial

A cluster randomized controlled trial comparing relative effectiveness of two licensed influenza vaccines in US nursing homes: Design and rationale

Assessing survival benefit when treatment delays disease progression

Seeking harmony: estimands and sensitivity analyses for confirmatory clinical trials

Research involving pediatric stem cell donors: A way forward

The treatment of missing data in a large cardiovascular clinical outcomes study

Efficiencies of platform clinical trials: A vision of the future

Recruitment strategies at the Iowa site for parent/infant pairs in a longitudinal dental caries study

Remarks on designs enriching for placebo non-responders

Feasibility and clinical impact of sharing patient-reported symptom toxicities and performance status with clinical investigators during a phase 2 cancer treatment trial

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SCT Newsletter

SCT Newsletter Current Issue (vol 26,2):
President's Corner, Workshops, Seminars, Committee Updates, Webinars, Annual Meeting Promotion, Upcoming Events and more...
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David Sackett Trial of the Year

SCT Trial of the Year Award
8th Annual Award (2015)
“Mechanical versus Manual Chest Compression for Out-of-Hospital Cardiac Arrest (PARAMEDIC)”
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SCT Newsletter Society for Clinical Trials
An international professional organization dedicated to the theory and practice of clinical trials.
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